In "Why doesn't C-c a call the agenda? Why don't some org keybindings work?", we can see
#+BEGIN_SRC emacs-lisp
;; The following lines are always needed. Choose your own keys.
(add-to-list 'auto-mode-alist '("\\.org\\'" . org-mode))
(global-set-key "\C-cl" 'org-store-link)
(global-set-key "\C-ca" 'org-agenda)
(global-set-key "\C-cb" 'org-iswitchb)
#+END_SRC emacs-lisp