The extreme slowness happened again just know. When this happened, `org-end-of-line' command took forever until "C-g". M-x org-element-cache-reset worked this time, i.e., after running `org-element-cache-reset' command `org-end-of-line' became fast again. I was using commit "ca6ecf9", and the buffer was 38xx lines 168K in size.