Hi,

This is possible using Babel, the attached org-mode file will execute
its code block every time it is opened.  You can replace the contents of
the code block with any arbitrary elisp you would like to have executed
in the file.

To see this work, save the attached org-mode file to your system, open
the file, answer "y" to allow execution, and then check your messages
buffer for the "I have been run" message to see that the code block has
in fact been evaluated.

Best -- Eric